481-18-5

481-18-5 structure

Name: alpha-Spinasterol
Chemical Name: (3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS Number: 481-18-5
Molecular Formula: C₂₉H₄₈O
Molecular Weight: 412.691
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-30 20:34:46
Modify Date: 2024-01-02 20:52:03
α-Spinasterol, isolated from Spinacia oleracea, has antibacterial activity[1]. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively[2].

Name	(3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Synonyms	a-Spinasterin Bessisterol UNII:0LG993QX1A Spinasterol (3b,5a,22E)-Stigmasta-7,22-dien-3-ol Alpha-Spinasterol spinasta-7,22-dien-3-ol Hitodesterol Chondrillasterol a-Spinasterol Stigmasta-7,22-dien-3-ol, (3β,5α,22E)- α-Spinasterin (3β,5α,22E)-Stigmasta-7,22-dien-3-ol

Description	α-Spinasterol, isolated from Spinacia oleracea, has antibacterial activity[1]. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> COX Research Areas >> Neurological Disease
Target	COX-1:16.17 μM (IC50) COX-2:7.76 μM (IC50) TRPV1
References	[1]. Brusco I, et al. α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. Br J Pharmacol. 2017 Dec;174(23):4247-4262. [2]. Yang X, et al. A novel method for synthesis of α-spinasterol and its antibacterial activities in combination with ceftiofur. Fitoterapia. 2017 Jun;119:12-19.

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 20,257,1985

Hazard Codes	Xi