129075-73-6
129075-73-6 structure
- Name: DPQ
- Chemical Name: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone
- CAS Number: 129075-73-6
- Molecular Formula: C18H26N2O2
- Molecular Weight: 302.41
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2018-05-31 08:00:00
- Modify Date: 2024-01-05 12:04:07
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DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection[1].
| Name | 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone |
|---|---|
| Synonyms |
5-[4-(1-Piperidinyl)-butyloxy]-1,2,3,4-tetrahydroisoquinolin-1-one
5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]- 5-[4-(1-Piperidinyl)butoxy]-3,4-dihydro-1(2H)-isoquinolinone 5-[4-(Piperidin-1-yl)butoxy]-3,4-dihydroisoquinolin-1(2H)-one |
| Description | DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection[1]. |
|---|---|
| Related Catalog | |
| Target |
PARP-1[1] |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 528.8±50.0 °C at 760 mmHg |
| Molecular Formula | C18H26N2O2 |
| Molecular Weight | 302.41 |
| Flash Point | 273.6±30.1 °C |
| Exact Mass | 302.199432 |
| PSA | 41.57000 |
| LogP | 2.25 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.544 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |