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102-60-3

102-60-3 structure
102-60-3 structure
Name N,N,N,N-Tetrakis(2-Hydroxypropyl)- Ethylenediamine
Synonyms Edetol
1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-ol
1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol)
1,1',1'',1'''-(Ethylenedinitrilo)-tetra-2-propanol
N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
Quadrol
N,N,N’N’-tetra(2-hydropropyl)ethylene diamine
THPE
1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol
Entprol
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
EINECS 203-041-4
1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetra(2-propanol)
MFCD00004534
1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetrakis[2-propanol]
Ethylenediamine-N,N,N',N'-tetra-2-propanol
EDTP
Description Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing.
Related Catalog
In Vitro Results show that viability of macrophages incubated with Quadrol at concentrations of 0.5 mM, 1 mM and 4mM are identical to that for controls. Viability, however, is reduced to 50% of control at concentrations of 16 mM to 32 mM. After four hours, at concentrations of 1 mM and 4 mM, Quadrol produces enhanced spreading of 88% and 80%, respectively, as compared to the control of 28%. Quadrol, at a concentration of 16 mM, shows reduced percentage of spreading of macrophages after four hours. Exposure of macrophages to 1.0 mM or 4.0 mM Quadrol concentrations enhances phagocytic activity, 41% and 57%, respectively, over that of the cells exposed to media alone (34%)[1].
In Vivo On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5)[2].
Cell Assay The standard trypan blue exclusion test is performed to measure cell viability (10). Cells are exposed to increasing concentrations of Quadrol (0.5 mM to 32 mM) and incubated at 37°C for varying lengths of time before treatment with trypan blue[1].
Animal Admin At the time of polytetrafluoroethylene (PTFE) tubing implantation, six test groups (3 streptozotocin-induced (STZ) diabetic and 3 non-diabetic) consisting of 5 to 7 animals per sampling time receive either diluent (control group) or Quadrol (10 mM) injected approximately 1 cm from the implantation site. The PTFE implants recovered from the mice after 2 to 14 days are stored frozen until processed and then analyzed by the HPLC method[2].
References

[1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12.

[2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22.
Density 1.1±0.1 g/cm3
Boiling Point 369.1±0.0 °C at 760 mmHg
Melting Point 32°C
Molecular Formula C14H32N2O4
Molecular Weight 292.415
Flash Point 145.7±17.4 °C
Exact Mass 292.236206
PSA 87.40000
LogP 0.13
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.517
Water Solubility miscible

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UB5604000
CHEMICAL NAME :
2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-
CAS REGISTRY NUMBER :
102-60-3
BEILSTEIN REFERENCE NO. :
1781143
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H32-N2-O4
MOLECULAR WEIGHT :
292.48
WISWESSER LINE NOTATION :
QY1&1N1YQ1&2N1YQ1&1YQ1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 52,762,1991
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 52,762,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C258,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1905 No. of Facilities: 152 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 3701 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1905 No. of Facilities: 141 (estimated) No. of Industries: 15 No. of Occupations: 16 No. of Employees: 3730 (estimated) No. of Female Employees: 1831 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R43
Safety Phrases S36/37-S37-S24
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UB5604000
HS Code 29221980
107-15-3 structure

107-15-3

75-56-9 structure

75-56-9

~%

102-60-3 structure

102-60-3

Literature: US2697118 , ;
107-15-3 structure

107-15-3

75-56-9 structure

75-56-9

~%

123-84-2 structure

123-84-2

3270-73-3 structure

3270-73-3

Detail
Literature: Polish Journal of Chemistry, , vol. 54, # 11/12 p. 2201 - 2208
10507-78-5 structure

10507-78-5

75-56-9 structure

75-56-9

~%

123-84-2 structure

123-84-2

3270-73-3 structure

3270-73-3

Detail
Literature: Polish Journal of Chemistry, , vol. 54, # 11/12 p. 2201 - 2208
Precursor  3

DownStream  0

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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