579-38-4

579-38-4 structure

Name: Diloxanide
Chemical Name: 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
CAS Number: 579-38-4
Molecular Formula: C₉H₉Cl₂NO₂
Molecular Weight: 234.07900
Catalog: API Antiparasitic drug Anti-amebiasis and anti-trichomoniasis drugs
Create Date: 2018-07-23 17:42:05
Modify Date: 2024-01-02 16:08:42
Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].

Name	2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
Synonyms	Diloxanid Amebamida EINECS 209-439-4 Diloxanide RD 3803 Acetamide,2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl Diloxanidum [INN-Latin] Entamide Ame-boots Diloxanida [INN-Spanish]

Description	Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].
Related Catalog	Research Areas >> Infection
In Vivo	Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1]. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].
References	[1]. DB08792 [2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

Precursor 0
DownStream 1
3686-72-4