Diloxanide
Modify Date: 2025-09-01 11:52:10
Diloxanide structure
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Common Name | Diloxanide | ||
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| CAS Number | 579-38-4 | Molecular Weight | 234.07900 | |
| Density | 1.439g/cm3 | Boiling Point | 356.2ºC at 760 mmHg | |
| Molecular Formula | C9H9Cl2NO2 | Melting Point | 175° | |
| MSDS | N/A | Flash Point | 169.2ºC | |
Use of DiloxanideDiloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1]. |
| Name | 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide |
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| Synonym | More Synonyms |
| Description | Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1]. |
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| Related Catalog | |
| In Vivo | Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1]. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2]. |
| References |
[1]. DB08792 |
| Density | 1.439g/cm3 |
|---|---|
| Boiling Point | 356.2ºC at 760 mmHg |
| Melting Point | 175° |
| Molecular Formula | C9H9Cl2NO2 |
| Molecular Weight | 234.07900 |
| Flash Point | 169.2ºC |
| Exact Mass | 233.00100 |
| PSA | 40.54000 |
| LogP | 2.15870 |
| Index of Refraction | 1.615 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Precursor 0 | |
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| DownStream 1 | |
![[4-[(2,2-dichloroacetyl)-methylamino]phenyl] 4-methylsulfonylbenzoate structure](https://image.chemsrc.com/caspic/162/3686-72-4.png)
CAS#:3686-72-4| Diloxanid |
| Amebamida |
| EINECS 209-439-4 |
| Diloxanide |
| RD 3803 |
| Acetamide,2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl |
| Diloxanidum [INN-Latin] |
| Entamide |
| Ame-boots |
| Diloxanida [INN-Spanish] |