Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Decursin
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Decursin
Price: ￥1668.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Decursin ((+)-Decursin)
Price: $600.0/100mg $1100.0/250mg $2300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Decursin ((+)-Decursin)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DECURSIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

5928-25-6

5928-25-6 structure

5928-25-6 structure

Name: Decursin
Chemical Name: decursin
CAS Number: 5928-25-6
Molecular Formula: C₁₉H₂₀O₅
Molecular Weight: 328.359
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-02-16 08:00:00
Modify Date: 2024-01-02 12:37:19
Decursin is an anticancer agent, with potential anti-inflammatory activity.

Name	decursin
Synonyms	(S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo(1,2-b:5,4-b')dipyran-7-yl 3-methyl-2-butenoate 2-Butenoic acid, 3-methyl-, 7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo(1,2-b:5,4-b')dipyran-7-yl ester, (S)- (7S)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl 3-methylbut-2-enoate 2-Butenoic acid, 3-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester (7S)-8,8-Dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl 3-methyl-2-butenoate (S)-8,8-Dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano(3,2-g)chromen-7-yl 3-methyl-2-butenoate

Description	Decursin is an anticancer agent, with potential anti-inflammatory activity.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Decursin (25-100 μM) shows a strong dose- and time-dependent inhibition of cell growth, accounting for 22% to 51%, 21% to 68%, 9% to 72%, and 42% to 90% growth inhibition after 24, 48, 72, and 96 hours of treatment, respectively. Furthermore, it is observed that both Decursin and Decursinol have cytotoxic effect on DU145 cells, in which similar treatment (25-100 μM for 24, 48, 72, and 96 hours) with Decursin cause 15% to 45% cell death versus 11% to 12% in controls[1]. Decursin blocks tumor progression by suppression of angiopoietin-2, angiopoietin receptor Tie-2, and endothelial nitric oxide synthase (eNOS) in endothelial progenitor cells. Decursin has the ability to inhibit vascular endothelial growth factor (VEGF)-induced proliferation, metastasis, and tube formation in human umbilical vein endothelial cells (HUVECs). Decursin inhibits pro-inflammatory molecules, such as chemokines, cytokines, and enzymes such as Cyclooxygenase-2 (COX-2) and MMPs[2].
Cell Assay	To assess the biological activity of these compounds in terms of cell growth and death, DU145 cells are treated with 25, 50, and 100 μM doses of Decursin and Decursinol for 24, 48, 72, and 96 hours[1].
References	[1]. Yim D, et al. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 2005 Feb 1;65(3):1035-44. [2]. Shehzad A, et al. Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases. Inflamm Res. 2018 Mar;67(3):209-218.

Density	1.2±0.1 g/cm3
Boiling Point	469.4±45.0 °C at 760 mmHg
Melting Point	93-94ºC
Molecular Formula	C₁₉H₂₀O₅
Molecular Weight	328.359
Flash Point	206.6±28.8 °C
Exact Mass	328.131073
PSA	65.74000
LogP	4.57
Appearance	white to beige
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.580
Storage condition	?20°C
Water Solubility	DMSO: soluble5mg/mL, clear

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29322090