Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Hydroxyflutamide
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hydroxyflutamide
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Purity: 98.0%
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52806-53-8

52806-53-8 structure

52806-53-8 structure

Name: 2-Hydroxyflutamide
Chemical Name: Hydroxy Flutamide
CAS Number: 52806-53-8
Molecular Formula: C₁₁H₁₁F₃N₂O₄
Molecular Weight: 292.211
Create Date: 2018-03-26 08:00:00
Modify Date: 2025-08-20 07:34:19
Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2].

Name	Hydroxy Flutamide
Synonyms	2-hydroxy Flutamide 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide Hydroxyflutamide 2-Hydroxy-flutamide

Description	Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
Target	IC50: 700 nM (androgen receptor)[1]
References	[1]. Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96. [2]. Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18(9):1823.

Density	1.5±0.1 g/cm3
Boiling Point	443.8±45.0 °C at 760 mmHg
Melting Point	125-130â„ƒ
Molecular Formula	C₁₁H₁₁F₃N₂O₄
Molecular Weight	292.211
Flash Point	222.2±28.7 °C
Exact Mass	292.067078
PSA	95.15000
LogP	3.16
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.546

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX1466250

CHEMICAL NAME :: Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phen yl)-

CAS REGISTRY NUMBER :: 52806-53-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H11-F3-O2-N4

MOLECULAR WEIGHT :: 288.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg/6D-I

TOXIC EFFECTS :: Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 1,297,1981 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 11-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

REFERENCE :: CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 73,1582,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2400 mg/kg

SEX/DURATION :: female 15-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male

REFERENCE :: CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 73,1582,1995

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	TX1466250
HS Code	2924299090

Precursor 5
2110-78-3 393-11-3 62100-51-0 88-30-2
62100-47-4
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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