49625-89-0

49625-89-0 structure

Name: 6β-Naltrexol
Chemical Name: 6β-Naltrexol
CAS Number: 49625-89-0
Molecular Formula: C₂₀H₂₅NO₄
Molecular Weight: 343.42
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-12-13 17:10:28
Modify Date: 2026-07-02 11:54:47
6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1].

Name	6β-Naltrexol
Synonyms	6β-Naltrexol solution 6-β-Naltrexol hydrate in methanol 6-Hydroxynaltrexone 6β-Naltrexol (CRM) 6 beta-hydroxynaltrexone (5a,6a)-17-(Cyclopropylmethyl)-4,5-oxy-morphinan-3,6,14-triol 6β-Naltrexol (1.0 mg/mL in Methanol) 6b-Naltrexo Nalfurafine Impurity 30 17-(CyclopropylMethyl)-4,5-oxy-(5α,6β)-Morphinan-3,6,14-triol 17-(Cyclopropylmethyl)-4,5-oxy-(5a,6b)-morphinan-3,6,14-triol NALTREXOL a-Naltrexol 6a-Hydroxynaltrexone 6-beta-Naltrexol, 1mg/ml in Methanol (4R,4aS,7R,7,12bS)-3-(cyclopropylmethyl)-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol 17-(Cyclopropylmethyl)-4,5a-oxy-morphinan-3,6a,14-triol 6-Naltrexol 6-BETA-NALTREXOL HCL 6-β-Naltrexol HCl 6β-Naltrexol (1.0mg/ml in DMSO) (4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol 6b-Hydroxynaltrexone b-Naltrexol Naltrexone Impurity 31 Morphinan-3,6,14-triol, 17-(cyclopropylmethyl)-4,5-oxy-, (5α,6β) 6.beta.-Naltrexol (CRM) 17-(Cyclopropylmethyl)-4,5-oxy-(5a,6)-morphinan-3,6,14-triol

Description	6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
References	[1]. Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64(4):618-21. [2]. Yancey-Wrona J, et al. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011 Dec;12(12):1727-37.

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution