21499-66-1

21499-66-1 structure

Name: Bruceine D
Chemical Name: bruceine D
CAS Number: 21499-66-1
Molecular Formula: C₂₀H₂₆O₉
Molecular Weight: 410.415
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-09-06 11:36:22
Modify Date: 2026-07-01 20:51:52
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2].

Name	bruceine D
Synonyms	Nsc318801 BRUCEIND (1β,9ξ,11β,12α,15β)-1,11,12,14,15-Pentahydroxy-13,20-epoxypicras-3-ene-2,16-dione (1R,2S,3R,3,3a1R,4R,6,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-oxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione (1beta,11beta,12alpha,15beta)-13,20-oxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione (1R,2S,3R,3,3a1R,4R,6,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-oxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione (1R,2R,3R,6R,8S,12S,13S,14R,15R,16S,17R)-2,3,12,15,16-pentahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-4,11-dione Pasite,Notch,Apoptosis,Bruceine D,Inhibitor,inhibit (1R,2S,3R,3,3a1R,4R,6,7aS,11S,11aS,11bR)-1,2,3a,4,11-Pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-oxymethano)dibenzo[de,g]chromen-5,10(6aH,11bH)-dione Picras-3-ene-2,16-dione, 13,20-oxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β) Bruceine D, 10 mM in DMSO

Description	Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Stem Cell/Wnt >> Notch
Target	Notch[1]
In Vitro	Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1]. Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].
References	[1]. Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. [2]. Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205.