3414-62-8

3414-62-8 structure

Name: 6-n-hydroxyadenosine
Chemical Name: 6-n-hydroxyadenosine
CAS Number: 3414-62-8
Molecular Formula: C₁₀H₁₃N₅O₅
Molecular Weight: 283.24100
Catalog: Research Areas Others
Create Date: 2016-02-23 20:56:53
Modify Date: 2024-01-03 09:10:55
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells[1][2].

Name	6-n-hydroxyadenosine
Synonyms	N6-Hydroxy-5-methyl-cytosin N6-hydroxyadenosine N-hydroxyadenosine 5-methyl-1H-pyrimidine-2,4-dione 4-oxime 6-(hydroxyamino)-5-methylpyrimidin-2(1h)-one 5-Methyl-N(4)-hydroxycytosine

Description	Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells[1][2].
Related Catalog	Research Areas >> Others
In Vitro	Inosine oxime (6-Hydroxyadenosine) (1-5 nM) has reductive detoxication through direct dehydroxylamination catalyzed by adenosine deaminase to inosine and decreases inosine formation by 35% with knockdown of mARC1 in HEK-293.
References	[1]. Plitzko B, et, al. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. [2]. Krompholz N, et, al. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chem Res Toxicol. 2012 Nov 19;25(11):2443-50.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,231,1985

Precursor 0
DownStream 1
58-61-7