6-n-hydroxyadenosine

Modify Date: 2024-01-03 09:10:55

6-n-hydroxyadenosine structure	Common Name	6-n-hydroxyadenosine
	CAS Number	3414-62-8	Molecular Weight	283.24100
	Density	2.12g/cm3	Boiling Point	703.7ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₃N₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	379.4ºC

Use of 6-n-hydroxyadenosine

Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells[1][2].

Name	6-n-hydroxyadenosine
Synonym	More Synonyms

Description	Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells[1][2].
Related Catalog	Research Areas >> Others
In Vitro	Inosine oxime (6-Hydroxyadenosine) (1-5 nM) has reductive detoxication through direct dehydroxylamination catalyzed by adenosine deaminase to inosine and decreases inosine formation by 35% with knockdown of mARC1 in HEK-293.
References	[1]. Plitzko B, et, al. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. [2]. Krompholz N, et, al. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chem Res Toxicol. 2012 Nov 19;25(11):2443-50.

Density	2.12g/cm3
Boiling Point	703.7ºC at 760 mmHg
Molecular Formula	C₁₀H₁₃N₅O₅
Molecular Weight	283.24100
Flash Point	379.4ºC
Exact Mass	283.09200
PSA	149.01000
Index of Refraction	1.897

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6475000

CHEMICAL NAME :: Adenine, N-hydroxy-9-ribofuranosyl-

CAS REGISTRY NUMBER :: 3414-62-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IMQ DO1- BT5OTJ CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 700 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ng/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,231,1985

Precursor 0
DownStream 1
CAS#:58-61-7 Adenosine

N6-Hydroxy-5-methyl-cytosin

N6-hydroxyadenosine

N-hydroxyadenosine

5-methyl-1H-pyrimidine-2,4-dione 4-oxime

6-(hydroxyamino)-5-methylpyrimidin-2(1h)-one

5-Methyl-N(4)-hydroxycytosine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-N-HYDROXYADENOSINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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