38241-28-0

38241-28-0 structure

Name: Zinterol hydrochloride
Chemical Name: Zinterol hydrochloride
CAS Number: 38241-28-0
Molecular Formula: C₁₉H₂₇ClN₂O₄S
Molecular Weight: 414.94700
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2016-05-22 18:05:10
Modify Date: 2024-01-05 12:41:40
Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3].

Name	Zinterol hydrochloride
Synonyms	N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide,hydrochloride

Description	Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β2-adrenoceptor[1]
In Vivo	Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3]. Animal Model: In New Zealand White HF rabbits of either sex[3] Dosage: 1.0 or 2.5 μg/kg Administration: Intravenous bolus administration; over 5 seconds Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
References	[1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca²⁺ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97.

Boiling Point	574.3ºC at 760 mmHg
Molecular Formula	C₁₉H₂₇ClN₂O₄S
Molecular Weight	414.94700
Flash Point	301.1ºC
Exact Mass	414.13800
PSA	107.04000
LogP	4.75470

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB0512953

CHEMICAL NAME :: Methanesulfonanilide, 5'-(2-((alpha,alpha-dimethylphenethyl)amino)-1-hydrox yethyl)-2'- hydroxy-, monohydrochloride

CAS REGISTRY NUMBER :: 38241-28-0

LAST UPDATED :: 199007

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H26-N2-O4-S.Cl-H

MOLECULAR WEIGHT :: 414.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,626,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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