128-13-2
128-13-2 structure
- Name: Ursodiol
- Chemical Name: Ursodeoxycholic acid
- CAS Number: 128-13-2
- Molecular Formula: C24H40O4
- Molecular Weight: 392.572
- Catalog: API Digestive system medication Biliary medicine
- Create Date: 2018-02-04 08:00:00
- Modify Date: 2026-06-30 12:19:59
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Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation.
| Name | Ursodeoxycholic acid |
|---|---|
| Synonyms |
(3a,5b,7b,8x)-3,7-dihydroxycholan-24-oic acid
Ursofalk URSODESOXYCHOLIC ACID 17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7b-diol Ursocol 3α,7β-Dihydroxy-6β-cholan-24-oic acid Ursodiol (Ursodeoxycholic Acid) Ursodeoxycholic acid,3α,7β-Dihydroxy-5β-cholan-24-oic acid, 5β-Cholan-24-oic acid-3α,7β-diol, 7β-Hydroxylithocholic acid, UDCS Ursochol Tauroursodiol Actigall Delursan urso Urosodeoxycholic Acid 3a,7b-dihydroxy-5b-cholan-24-oic acid 3,7-dihydroxy-,(3-alpha,5-beta,7-beta)-cholan-24-oicaci (3α,5β,7β,8ξ,20R)-3,7-Dihydroxycholan-24-oic acid litursol Cholit-ursan Ursodeoxycholic acid(micronized) Desol (3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7b)- (9CI) ursobilin Ursacol Desocol Urodeoxycholic acid 17-beta-(1-methyl-3-cboxypropyl)etiocholane-3-alpha,7-beta-diol 3-alpha,7-beta-dihydroxycholanicacid MFCD00003680 actigall ursacol 7b-Hydroxylithocholic acid 3a,7b-Dihydroxy-5b-cholanic acid Arsacol 3a,7b-Dihydroxy-5b-cholan-24-oate 5b-Cholanic acid, 3a,7b-dihydroxy- (7CI) delursan URSODIOL Ursolvan Peptarom (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid ursochol (3α,5β,7β)-3,7-Dihydroxycholan-24-oic acid URSODEOXYCHOLIC ACID URSODEOXYCHOLOC ACID 3a,7b-Dihydroxycholanic acid ptom deursil Urdes Litursol 3a,7b-Dihydroxy-5b-cholanoic acid Ursodesoxycholic acid (UDCA) 3,7-Dihydroxycholan-24-oic acid 3α,7β-dihydroxy-5β-cholan-24-oic acid 3-alpha,7-beta-dihydroxy-5-beta-cholanoicacid 3α,7β-Dihydroxy-5β-cholan-24-oic acid, 5β-Cholan-24-oic acid-3α,7β-diol, 7β-Hydroxylithocholic acid, UDCS (3a,5b,7b)-3,7-Dihydroxycholan-24-oic Acid Ursodiol, 7-Hydroxylithocholic Acid URSODEOXYCHOLATE Ursodeoxycholic-2,2,3,4,4-d5 acid sacol 3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oicaci acidoursodeossicolico cholit-ursan 3a,7b-Dioxycholanic Acid Destolit destolit 5b-Cholan-24-oic acid, 3a,7b-dihydroxy- (8CI) Ursodeoxycholic acid，Ursodiol 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid 5beta-Cholanic Acid-3alpha,7beta-diol 3alpha,7beta-Dihydroxy-5beta-cholanic Acid solutrat Paptom lyeton EINECS 204-879-3 |
| Description | Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.Target: OthersUrsodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 547.1±25.0 °C at 760 mmHg |
| Melting Point | 203-206 ºC |
| Molecular Formula | C24H40O4 |
| Molecular Weight | 392.572 |
| Flash Point | 298.8±19.7 °C |
| Exact Mass | 392.292664 |
| PSA | 77.76000 |
| LogP | 4.66 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.543 |
| Storage condition | 2~8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | FZ2000000 |
