130018-77-8
130018-77-8 structure
- Name: Levocetirizine
- Chemical Name: Levocetirizine
- CAS Number: 130018-77-8
- Molecular Formula: C21H25ClN2O3
- Molecular Weight: 388.888
- Catalog: Research Areas Endocrinology
- Create Date: 2018-03-18 08:00:00
- Modify Date: 2026-07-23 00:03:41
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Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].
| Name | Levocetirizine |
|---|---|
| Synonyms |
2-(2-(4-((4-Chlorophenyl)
Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy] Levocetirizine [INN] vardenafilH 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride (2-(4-((R)-(4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid Vardenafil LevocetirizineHydrochloride alerlisin Cetirizine R-Isomer Levocetirizine (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1- yl)ethoxy)acetic acid Levocetirizine-IP/IHS levocetirizinum LEVOCETRIZINE Levocetirizine Hydrochloride IP (R)-Cetirizine LevocetirizineDihydrochloride LEVOCETIRIZINE Levocetirizine, 10 mM in DMSO Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine LevocetirizineQ: What is Levocetirizine Q: What is the CAS Number of Levocetirizine Q: What is the storage condition of Levocetirizine Cetirizine Impurity 20 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid Vivanza (R)-Cetirizine-d4 MFCD04112703 levocarnitine (R)-Cetirizine Dihydrochloride (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride (-)-Cetirizine Levocetirizine-d4 (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Benodanil Impurity 17 (Pyracbolid) Cetirizine-d4 |
| Description | Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. |
|---|---|
| Related Catalog | |
| Target |
H1 receptor |
| In Vivo | Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1]. Animal Model: 30 male Sprague-Dawley rats (8 weeks old; 200-250 g)[1] Dosage: 0.4 mg/kg Administration: Oral administration (Pharmacokinetic Analysis) Result: The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 542.1±45.0 °C at 760 mmHg |
| Melting Point | 205-208°C (dec.) |
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 388.888 |
| Flash Point | 281.6±28.7 °C |
| Exact Mass | 388.155365 |
| PSA | 53.01000 |
| LogP | 2.16 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.589 |
| Storage condition | -20°C Freezer |
| Hazard Codes | Xn |
|---|---|
| HS Code | 2933599090 |
| Precursor 6 | |
|---|---|
| DownStream 0 | |
![(R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide structure](https://image.chemsrc.com/caspic/066/1150310-67-0.png)
![1-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazine structure](https://image.chemsrc.com/caspic/056/300543-56-0.png)
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |