391210-00-7

391210-00-7 structure

Name: PD318088
Chemical Name: 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
CAS Number: 391210-00-7
Molecular Formula: C₁₆H₁₃BrF₃IN₂O₄
Molecular Weight: 561.089
Catalog: Biochemical Inhibitor Mitogen-activated protein kinase (MAPK) MEK inhibitor
Create Date: 2017-01-16 11:08:11
Modify Date: 2024-01-30 13:05:17
PD318088 is an allosteric MEK inhibitor.

Name	5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
Synonyms	cc-457 C16H13BrF3IN2O4 5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide S1568_Selleck Benzamide, 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- PD318088

Description	PD318088 is an allosteric MEK inhibitor.
Related Catalog	Research Areas >> Cancer
Target	MEK
References	[1]. Ohren JF, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. [2]. Han S, et al. Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73.