1213777-80-0

1213777-80-0 structure

Name: Triphendiol
Chemical Name: (3R,4S)-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
CAS Number: 1213777-80-0
Molecular Formula: C₂₂H₂₀O₄
Molecular Weight: 348.392
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-09-05 06:57:02
Modify Date: 2024-01-16 10:57:21
Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent[1].

Name	(3R,4S)-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
Synonyms	2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)- 3-(4-Hydroxyphenyl)-4-(4-methoxyphenyl)-7-chromanol NV-196 UNII-6I62LZU21D Triphendiol

Description	Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Triphen diol (0-10 μM, 48-120 h)可抑制胰腺细胞增殖并诱导细胞凋亡，作用于 HPAC 和 PANC-1 细胞的 IC50值为 8 μM，作用于 MIAPaCa-2 细胞的 IC50 值为 0.8 μM[1]。 Apoptosis Analysis[1] Cell Line: Human pancreatic cell lines HPAC, MIAPaCa-2, and PANC-1 Concentration: 10 μM Incubation Time: 48 h Result: Induced caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells, 60% of the cells were in the early stage of apoptosis, and 30% of the cells were in the late stage of apoptosis. Reduced Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
In Vivo	Triphen diol(50 mg/kg, oral gavage, daily, 15 days) 在雄性移植了 MIAPaCa2 细胞系的 Balb/c 裸鼠中，可以显著抑制肿瘤的增殖，并且可以与吉西他滨联用显示更好的疗效[1]。
References	[1]. Xiaohong Wang, et al. Triphendiol (NV-196), development of a novel therapy for pancreatic cancer. Anticancer Drugs. 2011 Sep;22(8):719-31.