| Description |
Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent[1].
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| Related Catalog |
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| In Vitro |
Triphen diol (0-10 μM, 48-120 h)可抑制胰腺细胞增殖并诱导细胞凋亡，作用于 HPAC 和 PANC-1 细胞的 IC50值为 8 μM，作用于 MIAPaCa-2 细胞的 IC50 值为 0.8 μM[1]。 Apoptosis Analysis[1] Cell Line: Human pancreatic cell lines HPAC, MIAPaCa-2, and PANC-1 Concentration: 10 μM Incubation Time: 48 h Result: Induced caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells, 60% of the cells were in the early stage of apoptosis, and 30% of the cells were in the late stage of apoptosis. Reduced Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
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| In Vivo |
Triphen diol(50 mg/kg, oral gavage, daily, 15 days) 在雄性移植了 MIAPaCa2 细胞系的 Balb/c 裸鼠中，可以显著抑制肿瘤的增殖，并且可以与吉西他滨联用显示更好的疗效[1]。
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| References |
[1]. Xiaohong Wang, et al. Triphendiol (NV-196), development of a novel therapy for pancreatic cancer. Anticancer Drugs. 2011 Sep;22(8):719-31.
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