160492-56-8

160492-56-8 structure

Name: Osanetant
Chemical Name: N-(1-{3-[(3R)-1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]prop yl}-4-phenyl-4-piperidinyl)-N-methylacetamide
CAS Number: 160492-56-8
Molecular Formula: C₃₅H₄₁Cl₂N₃O₂
Molecular Weight: 606.62500
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-04-03 08:00:00
Modify Date: 2024-01-13 16:49:22
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for the treatment of schizophrenia[1].

Name	N-(1-{3-[(3R)-1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]prop yl}-4-phenyl-4-piperidinyl)-N-methylacetamide

Description	Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for the treatment of schizophrenia[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK3
In Vivo	Osanetant (SR142801; po; 1-10 mg/kg; 60 min before testing) significantly increases social interaction time[1]. Osanetant (ip; 5 and 10 mg/kg; 30 min before testing) decreases immobility time[1]. Animal Model: Male Mongolian gerbils of 7 weeks old (50-60 g)[1] Dosage: 1, 3 and 10 mg/kg Administration: Po; 60 min before testing Result: Significantly increased social interaction time.
References	[1]. Salomé N, et al. Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils. Pharmacol Biochem Behav. 2006 Apr;83(4):533-9.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport