84211-05-2
84211-05-2 structure
- Name: Mafosfamide Sodium Salt
- Chemical Name: 2-({2-[Bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-y l}sulfanyl)ethanesulfonic acid
- CAS Number: 84211-05-2
- Molecular Formula: C9H18Cl2N2NaO5PS2
- Molecular Weight: 401.26700
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-01-10 13:40:46
- Modify Date: 2025-08-27 10:38:30
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Mafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity[1][2].
| Name | 2-({2-[Bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-y l}sulfanyl)ethanesulfonic acid |
|---|
| Description | Mafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity[1][2]. |
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| Related Catalog | |
| In Vitro | Mafosfamide sodium salt (Z 7557 sodium salt; 2-10 μg/ml; 72 hours) triggers apoptosis in a dose and time dependent manner[1]. Mafosfamide sodium salt (2-10 μg/ml; 24 hours) causes the cells accumulated in S-phase[1]. Mafosfamide sodium salt (10 μg/ml; 24-72 hours) causes p53 stabilization[1]. Mafosfamide sodium salt (10 μg/ml) induces transcriptional inhibition that contributes to the apoptotic response combined with α-amanitin[1]. Apoptosis Analysis[1] Cell Line: TK6 and WTK1 cells Concentration: 2, 10 μg/ml Incubation Time: 72 hours Result: Triggered apoptosis in a dose and time dependent manner. Preferentially induced apoptosis (> 70% of dead cells) in both p53wt and p53mt cells, with necrosis only induced at low levels (< 30% of dead cells). Cell Cycle Analysis[1] Cell Line: TK6 and WTK1 cells Concentration: 2, 10 μg/ml Incubation Time: 24 hours Result: The cells accumulated in S-phase. Western Blot Analysis[1] Cell Line: TK6 and WTK1 cells Concentration: 10 μg/ml Incubation Time: 24, 48, 72 hours Result: Caused p53 stabilization by phosphorylation of Ser15, 20 and 37, and activation of ATM/ATR and Chk1/Chk2. |
| References |
| Molecular Formula | C9H18Cl2N2NaO5PS2 |
|---|---|
| Molecular Weight | 401.26700 |
| Exact Mass | 399.98500 |
| PSA | 139.43000 |
| LogP | 3.24070 |