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Product Name: (R*,R*)-(-)-2-(alpha-acetoxybenzyl)piperidinium chloride
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23257-56-9

23257-56-9 structure

23257-56-9 structure

Name: Levophacetoperane (hydrochloride)
Chemical Name: [phenyl(piperidin-4-yl)methyl] acetate,hydrochloride
CAS Number: 23257-56-9
Molecular Formula: C₁₄H₂₀ClNO₂
Molecular Weight: 269.76700
Catalog: Signaling Pathways Neuronal Signaling Dopamine Transporter
Create Date: 2017-11-03 18:43:31
Modify Date: 2026-07-02 15:35:21
Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.

Name	[phenyl(piperidin-4-yl)methyl] acetate,hydrochloride
Synonyms	Lidepran hydrochloride Levophacetoperan hydrochloride 1-Phenyl-1-(2-piperidyl)-1-acetoxymethane hydrochloride (R,R)-(-)-2-(alpha-acetoxybenzyl)piperidinium chloride Levophacetoperane Hyrochloride alpha-Phenyl-2-piperidinemethanol acetate hydrochloride Phenyl-(2-piperidyl)methyl acetate hydrochloride Levophacetoperan HCl Levophacetoperane hydrochloride 8228RP Levophacetoperane HCl 2-Piperidinemethanol, alpha-phenyl-, acetate (ester), hydrochloride Einecs -8 RP 8228 Lidran hydrochloride EINECS 245-536-8 Lidran

Description	Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease
Target	Norepinephrin uptake[1] Dopamine uptake[1]
In Vitro	Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake in Rat hypothalamus and cortex, and dopamine uptake in corpus striatum and cortex. Levophacetoperane is a psychostimulant[1]. Levophacetoperane has been used as an antidepressant and anorectic. Levophacetoperane is the reverseester of methylphenidate.
References	[1]. Ramirez A, et al. [Effects of levophacetoperane, pemoline, fenozolone, and centrophenoxine on catecholamines and serotonin uptake in various parts of the rat brain]. C R Acad Sci Hebd Seances Acad Sci D. 1978 Jul 3;187(1):53-6.

Density	1.07g/cm3
Boiling Point	325.1ºC at 760mmHg
Molecular Formula	C₁₄H₂₀ClNO₂
Molecular Weight	269.76700
Flash Point	150.4ºC
Exact Mass	269.11800
PSA	38.33000
LogP	3.56370

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN1050000

CHEMICAL NAME :: 2-Piperidinemethanol, alpha-phenyl-, acetate (ester), hydrochloride

CAS REGISTRY NUMBER :: 23257-56-9

LAST UPDATED :: 199012

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H19-N-O2.Cl-H

MOLECULAR WEIGHT :: 269.80

WISWESSER LINE NOTATION :: T6MTJ DYR&OV1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 241,182,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 77 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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