23257-56-9

• 常用中文名：左法哌酯盐酸盐
• 常用英文名：Levophacetoperane (hydrochloride)
• CAS号：23257-56-9
• 分子式：C₁₄H₂₀ClNO₂
• 分子量：269.76700
• 相关类别： 信号通路 神经信号通路 多巴胺转运蛋白
• 发布时间：2017-11-03 18:43:31
• 更新时间：2024-01-04 23:27:42
• Levophacetoperane竞争性抑制去甲肾上腺素 (norepinephrin) 摄取和多巴胺 (dopamine) 摄取。

名称

• 中文名: 盐酸左旋茶碱
• 英文名: [phenyl(piperidin-4-yl)methyl] acetate,hydrochloride
• 英文别名: RP 8228; Phenyl-(2-piperidyl)methyl acetate hydrochloride; Levophacetoperan hydrochloride; 1-Phenyl-1-(2-piperidyl)-1-acetoxymethane hydrochloride; Lidepran hydrochloride; EINECS 245-536-8; Levophacetoperane hydrochloride; Levophacetoperane (hydrochloride)

物化性质

• 密度: 1.07g/cm3
• 沸点: 325.1ºC at 760mmHg
• 分子式: C₁₄H₂₀ClNO₂
• 分子量: 269.76700
• 闪点: 150.4ºC
• 精确质量: 269.11800
• PSA: 38.33000
• LogP: 3.56370
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Levophacetoperane竞争性抑制去甲肾上腺素 (norepinephrin) 摄取和多巴胺 (dopamine) 摄取。
• 相关类别:
  信号通路 >> 神经信号通路 >> 多巴胺转运蛋白
  研究领域 >> 神经疾病
• 靶点:

  Norepinephrin uptake[1] Dopamine uptake[1]

• 体外研究: Levophacetoperane以竞争方式体外抑制大鼠下丘脑和皮质中的去甲肾上腺素摄取,以及纹状体和皮质中的多巴胺摄取。 Levophacetoperane是一种精神兴奋剂[1]。 Levophacetoperane已被用作抗抑郁药和厌食药。 Levophacetoperane是哌甲酯的反向酯。
• 参考文献:

  [1]. Ramirez A, et al. [Effects of levophacetoperane, pemoline, fenozolone, and centrophenoxine on catecholamines and serotonin uptake in various parts of the rat brain]. C R Acad Sci Hebd Seances Acad Sci D. 1978 Jul 3;187(1):53-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TN1050000 CHEMICAL NAME : 2-Piperidinemethanol, alpha-phenyl-, acetate (ester), hydrochloride CAS REGISTRY NUMBER : 23257-56-9 LAST UPDATED : 199012 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C14-H19-N-O2.Cl-H MOLECULAR WEIGHT : 269.80 WISWESSER LINE NOTATION : T6MTJ DYR&OV1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 390 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 241,182,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

安全

• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%