Levophacetoperane (hydrochloride)

Modify Date: 2024-01-04 23:27:42

Levophacetoperane (hydrochloride) Structure
Levophacetoperane (hydrochloride) structure
Common Name Levophacetoperane (hydrochloride)
CAS Number 23257-56-9 Molecular Weight 269.76700
Density 1.07g/cm3 Boiling Point 325.1ºC at 760mmHg
Molecular Formula C14H20ClNO2 Melting Point N/A
MSDS N/A Flash Point 150.4ºC

 Use of Levophacetoperane (hydrochloride)


Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.

 Names

Name [phenyl(piperidin-4-yl)methyl] acetate,hydrochloride
Synonym More Synonyms

 Levophacetoperane (hydrochloride) Biological Activity

Description Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.
Related Catalog
Target

Norepinephrin uptake[1] Dopamine uptake[1]

In Vitro Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake in Rat hypothalamus and cortex, and dopamine uptake in corpus striatum and cortex. Levophacetoperane is a psychostimulant[1]. Levophacetoperane has been used as an antidepressant and anorectic. Levophacetoperane is the reverseester of methylphenidate.
References

[1]. Ramirez A, et al. [Effects of levophacetoperane, pemoline, fenozolone, and centrophenoxine on catecholamines and serotonin uptake in various parts of the rat brain]. C R Acad Sci Hebd Seances Acad Sci D. 1978 Jul 3;187(1):53-6.

 Chemical & Physical Properties

Density 1.07g/cm3
Boiling Point 325.1ºC at 760mmHg
Molecular Formula C14H20ClNO2
Molecular Weight 269.76700
Flash Point 150.4ºC
Exact Mass 269.11800
PSA 38.33000
LogP 3.56370

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN1050000
CHEMICAL NAME :
2-Piperidinemethanol, alpha-phenyl-, acetate (ester), hydrochloride
CAS REGISTRY NUMBER :
23257-56-9
LAST UPDATED :
199012
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C14-H19-N-O2.Cl-H
MOLECULAR WEIGHT :
269.80
WISWESSER LINE NOTATION :
T6MTJ DYR&OV1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 241,182,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
77 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

 Safety Information

HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

RP 8228
Phenyl-(2-piperidyl)methyl acetate hydrochloride
Levophacetoperan hydrochloride
1-Phenyl-1-(2-piperidyl)-1-acetoxymethane hydrochloride
Lidepran hydrochloride
EINECS 245-536-8
Levophacetoperane hydrochloride
Levophacetoperane (hydrochloride)
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