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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DEPUDECIN
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139508-73-9

139508-73-9 structure

139508-73-9 structure

Name: depudecin
Chemical Name: depudecin
CAS Number: 139508-73-9
Molecular Formula: C₁₁H₁₆O₄
Molecular Weight: 212.24200
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2016-11-10 10:05:26
Modify Date: 2025-08-25 18:51:42
Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola[1][2].

Name	depudecin
Synonyms	4,5:8,9-Dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeca-1,6-dienitol (−)-Depudecin (2R,3S,4S,5E,7S,8S,9R)-2,9-dihydroxy-3,4,7,8-diepoxy-undeca-5,10-diene 4,5:8,9-dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeco-1,6-dienitol * (1R)-[(2S,3S)-3-[(E)-2-[(2S,3S)-3-[(1R)-Hydroxyethyl]oxiran-2-yl]vinyl]oxiran-2-yl]-2-propen-1-ol (1R)-1-[(2S,3S)-3-[2-[(2S,3S)-3-[(1R)-1-hydroxyethyl]oxiran-2-yl]ethenyl]oxiran-2-yl]prop-2-en-1-ol

Description	Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC
In Vitro	Depudecin (48 h) 可以诱导由 ras 和 src 癌基因双重转化的 NIH3T3 细胞的扁平表型[1]。
References	[1]. Hannah T Reynolds, et al. Differential Retention of Gene Functions in a Secondary Metabolite Cluster. Mol Biol Evol. 2017 Aug 1;34(8):2002-2015. [2]. M Matsumoto, et al. Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola. J Antibiot (Tokyo). 1992 Jun;45(6):879-85.

Density	1.415g/cm3
Boiling Point	369.4ºC at 760mmHg
Molecular Formula	C₁₁H₁₆O₄
Molecular Weight	212.24200
Flash Point	177.2ºC
Exact Mass	212.10500
PSA	65.52000
LogP	0.00510
Vapour Pressure	5.83E-07mmHg at 25°C
Index of Refraction	1.706

Safety Phrases	S22

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