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139508-73-9

139508-73-9 structure
139508-73-9 structure
  • Name: depudecin
  • Chemical Name: depudecin
  • CAS Number: 139508-73-9
  • Molecular Formula: C11H16O4
  • Molecular Weight: 212.24200
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
  • Create Date: 2016-11-10 10:05:26
  • Modify Date: 2024-01-13 19:00:26
  • Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola[1][2].

Name depudecin
Synonyms 4,5:8,9-Dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeca-1,6-dienitol
(−)-Depudecin
(2R,3S,4S,5E,7S,8S,9R)-2,9-dihydroxy-3,4,7,8-diepoxy-undeca-5,10-diene
4,5:8,9-dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeco-1,6-dienitol
* (1R)-[(2S,3S)-3-[(E)-2-[(2S,3S)-3-[(1R)-Hydroxyethyl]oxiran-2-yl]vinyl]oxiran-2-yl]-2-propen-1-ol
(1R)-1-[(2S,3S)-3-[2-[(2S,3S)-3-[(1R)-1-hydroxyethyl]oxiran-2-yl]ethenyl]oxiran-2-yl]prop-2-en-1-ol
Description Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola[1][2].
Related Catalog
In Vitro Depudecin (48 h) 可以诱导由 ras 和 src 癌基因双重转化的 NIH3T3 细胞的扁平表型[1]。
References

[1]. Hannah T Reynolds, et al. Differential Retention of Gene Functions in a Secondary Metabolite Cluster. Mol Biol Evol. 2017 Aug 1;34(8):2002-2015.  

[2]. M Matsumoto, et al. Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola. J Antibiot (Tokyo). 1992 Jun;45(6):879-85.  

Density 1.415g/cm3
Boiling Point 369.4ºC at 760mmHg
Molecular Formula C11H16O4
Molecular Weight 212.24200
Flash Point 177.2ºC
Exact Mass 212.10500
PSA 65.52000
LogP 0.00510
Vapour Pressure 5.83E-07mmHg at 25°C
Index of Refraction 1.706
Safety Phrases S22