139652-86-1

139652-86-1 structure

Name: 6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl
Chemical Name: 6-[6-(4-hydroxypiperidin-1-yl)hexoxy]-3-methyl-2-phenylchromen-4-one,hydrochloride
CAS Number: 139652-86-1
Molecular Formula: C₂₇H₃₄ClNO₄
Molecular Weight: 472.01600
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2016-02-27 05:20:25
Modify Date: 2024-01-07 17:55:48
Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1].

Name	6-[6-(4-hydroxypiperidin-1-yl)hexoxy]-3-methyl-2-phenylchromen-4-one,hydrochloride
Synonyms	6-[6-(4-Hydroxypiperidinyl)hexoxy]-3-methyl-2-phenyl-4H-1-benzopyran-4-one hydrochloride 6-(6-(4-Hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl 4H-1-Benzopyran-4-one,6-((6-(4-hydroxy-1-piperidinyl)hexyl)oxy)-3-methyl-2-phenyl-,hydrochloride 6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone hydrochloride

Description	Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1] Ki: 4000 nM (Dopamine D2 receptor)[1]
In Vivo	Administration of Sigma-LIGAND-1 hydrochloride reverseS amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 hydrochloride and its structural analogues have the potential antipsychotic activity[1].
References	[1]. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.