168682-53-9

168682-53-9 structure

Name: ezatiostat
Chemical Name: ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate
CAS Number: 168682-53-9
Molecular Formula: C₂₇H₃₅N₃O₆S
Molecular Weight: 529.648
Catalog: Signaling Pathways Metabolic Enzyme/Protease Gutathione S-transferase
Create Date: 2017-10-06 06:56:54
Modify Date: 2024-01-11 15:22:08
Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

Name	ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate
Synonyms	Ethyl (2S)-2-amino-5-{[(2R)-3-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate Ter-199 TLK-199 ezatiostat UNII-057D10I8S8 Telintra Terrapin 199

Description	Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase Research Areas >> Cancer
In Vitro	Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].
References	[1]. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20.

RIDADR	NONH for all modes of transport