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37338-80-0

37338-80-0 structure
37338-80-0 structure
  • Name: orellanine
  • Chemical Name: 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one
  • CAS Number: 37338-80-0
  • Molecular Formula: C10H8N2O6
  • Molecular Weight: 252.18
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
  • Create Date: 2018-06-21 17:04:11
  • Modify Date: 2024-01-08 20:36:45
  • Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2].

Name 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one
Synonyms 3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide
Orellanin
2,2'-bipyridine-3,3',4,4'-tetrol-1,1'-dioxide
Orellanine
3,3',4,4'-Tetrahydroxy-2,2'-bipyridine-N,N'-dioxide
Description Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2].
Related Catalog
References

[1]. Lyons MJ, et al. Orellanine: From Fungal Origin to a Potential Future Cancer Treatment. J Nat Prod. 2023 Jun 23;86(6):1620-1631.  

[2]. Buvall L, et al. Orellanine specifically targets renal clear cell carcinoma. Oncotarget. 2017 Jul 25;8(53):91085-91098.  

Density 1.777 g/cm3
Boiling Point 834.615ºC at 760 mmHg
Molecular Formula C10H8N2O6
Molecular Weight 252.18
Flash Point 458.558ºC
Exact Mass 252.03800
PSA 124.92000
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%