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4444-42-2

4444-42-2 structure
4444-42-2 structure
  • Name: Desmethylnortriptyline
  • Chemical Name: 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)propan-1-amine
  • CAS Number: 4444-42-2
  • Molecular Formula: C18H19N
  • Molecular Weight: 249.35000
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-08-08 10:41:14
  • Modify Date: 2024-01-10 11:03:13
  • Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
Name 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)propan-1-amine
Synonyms Desmethylnortriptyline
N-desmethyl-nortriptyline
didesmethylamitriptyline
5-<3-Amino-propyliden>-10,11-dihydro-5H-dibenzo<a,d>cyclohepten
Description Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
Related Catalog
References

[1]. Burch JE, et al. Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde. J Chromatogr. 1983 May 13;274:350-4.

[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.
Density 1.127g/cm3
Boiling Point 399.2ºC at 760 mmHg
Molecular Formula C18H19N
Molecular Weight 249.35000
Flash Point 191.8ºC
Exact Mass 249.15200
PSA 26.02000
LogP 4.26600
Index of Refraction 1.664
HS Code 2921499090
40443-02-5 structure

40443-02-5

~%

4444-42-2 structure

4444-42-2
Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ; Location in patent: Paragraph 00102; 00103 ;
55090-31-8 structure

55090-31-8

~%

4444-42-2 structure

4444-42-2
Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ;
28860-39-1 structure

28860-39-1

~%

4444-42-2 structure

4444-42-2
Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ;
13099-16-6 structure

13099-16-6

~%

4444-42-2 structure

4444-42-2
Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ;
50-48-6 structure

50-48-6

~%

4444-42-2 structure

4444-42-2
Literature: Olesen, Ole V.; Linnet, Kristian Pharmacology, 1997 , vol. 55, # 5 p. 235 - 243
72-69-5 structure

72-69-5

~%

4444-42-2 structure

4444-42-2

47132-19-4 structure

47132-19-4
47132-16-1 structure

47132-16-1
Literature: Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929
HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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