Desmethylnortriptyline

Modify Date: 2024-01-10 11:03:13

Desmethylnortriptyline Structure
Desmethylnortriptyline structure
Common Name Desmethylnortriptyline
CAS Number 4444-42-2 Molecular Weight 249.35000
Density 1.127g/cm3 Boiling Point 399.2ºC at 760 mmHg
Molecular Formula C18H19N Melting Point N/A
MSDS N/A Flash Point 191.8ºC

 Use of Desmethylnortriptyline


Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

 Names

Name 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)propan-1-amine
Synonym More Synonyms

 Desmethylnortriptyline Biological Activity

Description Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
Related Catalog
References

[1]. Burch JE, et al. Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde. J Chromatogr. 1983 May 13;274:350-4.

[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

 Chemical & Physical Properties

Density 1.127g/cm3
Boiling Point 399.2ºC at 760 mmHg
Molecular Formula C18H19N
Molecular Weight 249.35000
Flash Point 191.8ºC
Exact Mass 249.15200
PSA 26.02000
LogP 4.26600
Index of Refraction 1.664

 Safety Information

HS Code 2921499090

 Synthetic Route

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Desmethylnortriptyline Structure

Desmethylnortri...

CAS#:4444-42-2

Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ; Location in patent: Paragraph 00102; 00103 ;

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Desmethylnortriptyline Structure

Desmethylnortri...

CAS#:4444-42-2

Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ;

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Desmethylnortriptyline Structure

Desmethylnortri...

CAS#:4444-42-2

Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ;

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Desmethylnortriptyline Structure

Desmethylnortri...

CAS#:4444-42-2

Literature: KANDULA, Mahesh Patent: WO2013/168008 A1, 2013 ;

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Desmethylnortriptyline Structure

Desmethylnortri...

CAS#:4444-42-2

Literature: Olesen, Ole V.; Linnet, Kristian Pharmacology, 1997 , vol. 55, # 5 p. 235 - 243

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Desmethylnortriptyline Structure

Desmethylnortri...

CAS#:4444-42-2

Literature: Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929

 Customs

HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

Desmethylnortriptyline
N-desmethyl-nortriptyline
didesmethylamitriptyline
5-<3-Amino-propyliden>-10,11-dihydro-5H-dibenzo<a,d>cyclohepten
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