Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: HIV-1 integrase inhibitor 8
Price: ￥4896.0/5g ￥7836.0/10g ￥1596.0/1g ￥736.0/250mg
Purity: 95.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: SPIROBIINDANE
Price: $450.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1568-80-5

1568-80-5 structure

1568-80-5 structure

Name: HIV-1 integrase inhibitor 8
Chemical Name: 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol
CAS Number: 1568-80-5
Molecular Formula: C₂₁H₂₄O₂
Molecular Weight: 308.41400
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIV Integrase
Create Date: 2018-12-26 08:02:58
Modify Date: 2024-01-02 09:25:53
HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].

Name	2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol
Synonyms	2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi<1H-indene>-6,6'-diol 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobisindane (2,2,3,3-tetrafluoropropoxy)acetic acid 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane 2,2,3,3-Tetrafluor-propyloxy-essigsaeure 3,3,3',3'-tetramethyl-1,1'-spirobisindane-6,6'-diol 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan SPIROBIINDANE

Description	HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase
In Vitro	HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1]. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1].
References	[1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem

Density	1.21±0.1 g/cm3(Predicted)
Boiling Point	478.5℃ at 760 mmHg
Melting Point	213-214 °C
Molecular Formula	C₂₁H₂₄O₂
Molecular Weight	308.41400
Flash Point	220.4℃
Exact Mass	308.17800
PSA	40.46000
LogP	4.74650
Vapour Pressure	8.84E-10mmHg at 25°C

HS Code	2906299090

Precursor 9
80-05-7 375-92-8 354-88-1 101-84-8
10528-65-1 58343-30-9 67-64-1 108-95-2
32507-22-5
DownStream 0

HS Code	2906299090
Summary	2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%