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1568-80-5

1568-80-5 structure
1568-80-5 structure
Name 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol
Synonyms 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi<1H-indene>-6,6'-diol
6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobisindane
(2,2,3,3-tetrafluoropropoxy)acetic acid
6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane
2,2,3,3-Tetrafluor-propyloxy-essigsaeure
3,3,3',3'-tetramethyl-1,1'-spirobisindane-6,6'-diol
6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan
SPIROBIINDANE
Description HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].
Related Catalog
In Vitro HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1]. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1].
References

[1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem
Density 1.21±0.1 g/cm3(Predicted)
Boiling Point 478.5℃ at 760 mmHg
Melting Point 213-214 °C
Molecular Formula C21H24O2
Molecular Weight 308.41400
Flash Point 220.4℃
Exact Mass 308.17800
PSA 40.46000
LogP 4.74650
Vapour Pressure 8.84E-10mmHg at 25°C
HS Code 2906299090
HS Code 2906299090
Summary 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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title: CAS No. 1568-80-5 | Chemsrc address: https://m.chemsrc.com/en/baike/1078395.html

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