36150-23-9

36150-23-9 structure

Name: Kobusin
Chemical Name: 5-[(3S,3aR,6S,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole
CAS Number: 36150-23-9
Molecular Formula: C₂₁H₂₂O₆
Molecular Weight: 370.39600
Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
Create Date: 2016-04-29 18:38:37
Modify Date: 2024-01-09 15:10:13
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].

Name	5-[(3S,3aR,6S,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole
Synonyms	Kobusin

Description	Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells[1].
In Vivo	In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice[1].
References	[1]. Yu Jiang , et al. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015 Nov 25;6:1041. [2]. Xing Zhang, et al. Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects. RSC Adv., 2017,7, 34236-34243.