215589-63-2

215589-63-2 structure
215589-63-2 structure
  • Name: FR-190809
  • Chemical Name: 1-cycloheptyl-1-[[4-(4-fluorophenoxy)phenyl]methyl]-3-[6-methyl-2,4-bis(methylsulfonyl)pyridin-3-yl]urea
  • CAS Number: 215589-63-2
  • Molecular Formula: C29H34FN3O6S2
  • Molecular Weight: 603.72500
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Acyltransferase
  • Create Date: 2017-08-16 13:28:13
  • Modify Date: 2024-01-29 19:14:52
  • FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].

Name 1-cycloheptyl-1-[[4-(4-fluorophenoxy)phenyl]methyl]-3-[6-methyl-2,4-bis(methylsulfonyl)pyridin-3-yl]urea
Synonyms Urea,N-cycloheptyl-N-((4-(4-fluorophenoxy)phenyl)methyl)-N'-(6-methyl-2,4-bis(methylsulfonyl)-3-pyridinyl)
UNII-1U8UW770Z6
Description FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].
Related Catalog
Target

IC50: (ACAT)[1]

In Vitro FR-190809 inhibits foam cell formation with an IC50 of 215 nM[1].
References

[1]. Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem. 1998 Oct 22;41(22):4408-20.

Molecular Formula C29H34FN3O6S2
Molecular Weight 603.72500
Exact Mass 603.18700
PSA 142.99000
LogP 8.06050
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