852947-39-8

852947-39-8 structure

Name: MB-07344
Chemical Name: [4-[(4-hydroxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenoxy]methylphosphonic acid
CAS Number: 852947-39-8
Molecular Formula: C₁₉H₂₅O₅P
Molecular Weight: 364.37
Catalog: Research Areas Metabolic Disease
Create Date: 2017-08-08 01:16:46
Modify Date: 2025-08-27 17:48:20
MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM[1].

Name	[4-[(4-hydroxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenoxy]methylphosphonic acid
Synonyms	unii-r1zw9h43zj

Description	MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM[1].
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Metabolic Disease
Target	Ki: 2.17 nM (Thyroid hormone receptor-β)[1]
In Vivo	MB-07344 (0.05 mg/kg; given i.v., 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with atorvastatin in normal rabbits[1]. Animal Model: Normal rabbits[1] Dosage: 0.05 mg/kg Administration: Given i.v., 3 times per week for 3 weeks Result: Combination with atorvastatin further reduced cholesterol.
References	[1]. Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156(3):454-65.