MB-07344

Modify Date: 2024-01-22 15:45:59

MB-07344 Structure
MB-07344 structure
Common Name MB-07344
CAS Number 852947-39-8 Molecular Weight 364.37
Density N/A Boiling Point N/A
Molecular Formula C19H25O5P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MB-07344


MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM[1].

 Names

Name [4-[(4-hydroxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenoxy]methylphosphonic acid
Synonym More Synonyms

 MB-07344 Biological Activity

Description MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM[1].
Related Catalog
Target

Ki: 2.17 nM (Thyroid hormone receptor-β)[1]

In Vivo MB-07344 (0.05 mg/kg; given i.v., 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with atorvastatin in normal rabbits[1]. Animal Model: Normal rabbits[1] Dosage: 0.05 mg/kg Administration: Given i.v., 3 times per week for 3 weeks Result: Combination with atorvastatin further reduced cholesterol.
References

[1]. Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156(3):454-65.

 Chemical & Physical Properties

Molecular Formula C19H25O5P
Molecular Weight 364.37
Exact Mass 364.14400
PSA 96.80000
LogP 4.23720

 Synonyms

unii-r1zw9h43zj