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875685-46-4

875685-46-4 structure
875685-46-4 structure
  • Name: 10-Nitro Oleic Acid
  • Chemical Name: 10-Nitrooleic Acid
  • CAS Number: 875685-46-4
  • Molecular Formula: C18H33NO4
  • Molecular Weight: 327.46
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2016-06-12 21:36:41
  • Modify Date: 2024-01-02 21:34:14
  • 10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].
Name 10-Nitrooleic Acid
Synonyms 10-Nitro Oleic Acid
Description 10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].
Related Catalog
In Vitro 10-Nitrooleic acid (5-25 μM; mouse keratinocytes) regulates expression of HO-1, hsp27, hsp70, Cox-2, and the glutathione-S-transferases GSTA1-2, GSTA3 and GSTA4 in a generally similar manner[1]. 10-Nitrooleic acid (10 μM; 0-6 hours) upregulates HO-1 protein in time- and concentration-dependent manners. 10-Nitrooleic acid also upregulates protein expression for Cox-2, hsp27, hsp70[1].
References

[1]. Garner RM, Mould DR, Chieffo C, Jorkasky DK. Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects. Clin Transl Sci. 2019;12(6):667-676.

[2]. Zheng R, et al. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 2014;67:1-9.

Molecular Formula C18H33NO4
Molecular Weight 327.46
Exact Mass 327.24100
PSA 83.12000
LogP 6.23610
4013-87-0 structure

4013-87-0

~%

875685-46-4 structure

875685-46-4

Literature: Gorczynski, Michael J.; Huang, Jinming; King, S. Bruce Organic Letters, 2006 ,  vol. 8,  # 11  p. 2305 - 2308
Precursor  1

DownStream  0


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