10-Nitro Oleic Acid

Modify Date: 2025-08-25 12:20:35

10-Nitro Oleic Acid Structure
10-Nitro Oleic Acid structure
Common Name 10-Nitro Oleic Acid
CAS Number 875685-46-4 Molecular Weight 327.46
Density N/A Boiling Point N/A
Molecular Formula C18H33NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 10-Nitro Oleic Acid


10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].

 Names

Name 10-Nitrooleic Acid
Synonym More Synonyms

 10-Nitro Oleic Acid Biological Activity

Description 10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].
Related Catalog
In Vitro 10-Nitrooleic acid (5-25 μM; mouse keratinocytes) regulates expression of HO-1, hsp27, hsp70, Cox-2, and the glutathione-S-transferases GSTA1-2, GSTA3 and GSTA4 in a generally similar manner[1]. 10-Nitrooleic acid (10 μM; 0-6 hours) upregulates HO-1 protein in time- and concentration-dependent manners. 10-Nitrooleic acid also upregulates protein expression for Cox-2, hsp27, hsp70[1].
References

[1]. Garner RM, Mould DR, Chieffo C, Jorkasky DK. Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects. Clin Transl Sci. 2019;12(6):667-676.

[2]. Zheng R, et al. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 2014;67:1-9.

 Chemical & Physical Properties

Molecular Formula C18H33NO4
Molecular Weight 327.46
Exact Mass 327.24100
PSA 83.12000
LogP 6.23610

 Synthetic Route

~%

10-Nitro Oleic Acid Structure

10-Nitro Oleic Acid

CAS#:875685-46-4

Literature: Gorczynski, Michael J.; Huang, Jinming; King, S. Bruce Organic Letters, 2006 ,  vol. 8,  # 11  p. 2305 - 2308

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

10-Nitro Oleic Acid
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