79498-31-0

79498-31-0 structure

Name: Glaucocalyxin A
Chemical Name: ent-7β,14α-Dihydroxy-16-kauren-3,15-dione
CAS Number: 79498-31-0
Molecular Formula: C₂₀H₂₈O₄
Molecular Weight: 332.434
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-27 20:55:54
Modify Date: 2024-01-03 08:45:33
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

Name	ent-7β,14α-Dihydroxy-16-kauren-3,15-dione
Synonyms	ent-7,14-Dihydroxy-16-kauren-3,15-dione Glaucocalyxin A (5β,7α,8α,9β,10α,13α,14R)-7,14-Dihydroxykaur-16-ene-3,15-dione

Description	Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	PI3K Akt
In Vitro	Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].
References	[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.