5673-36-9

5673-36-9 structure

Name: Dihydroisopimaric acid
Chemical Name: (1S,4aR,4bS,7S)-7-ethyl-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
CAS Number: 5673-36-9
Molecular Formula: C₂₀H₃₂O₂
Molecular Weight: 304.467
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2017-09-08 02:35:22
Modify Date: 2024-01-17 18:23:48
Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].

Name	(1S,4aR,4bS,7S)-7-ethyl-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
Synonyms	1-Phenanthrenecarboxylic acid,7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-,(1theta-(1alpha,4abeta,4balpha,7alpha,10aalpha)) Podocarp-7-en-15-oic acid,13alpha-ethyl-13-methyl Isopimaric acid,dihydro 1-Phenanthrenecarboxylic acid,7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-,(1R,4aR,4bS,7S,10aR) Isopimaric acid,delta7-dihydro (5ξ,13α)-Pimar-7-en-19-oic acid delta7-Dihydroisopimaric acid 1-Phenanthrenecarboxylic acid, 7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-, (1S,4aR,4bS,7S)- 15,16-Dihydroisopimaric acid Dihydroisopimaric acid

Description	Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	Effects of these compounds (10 microM) on the membrane potential of HEKBKalphabeta1 were monitored by use of DiBAC(4)(3), a voltage-sensitive dye. Dihydroisopimaric acid induces substantial membrane hyperpolarization. Dihydroisopimaric acid (1-10 microM) activates BKalphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].
References	[1]. Imaizumi Y, et al. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Mol Pharmacol. 2002;62(4):836-846.