Dihydroisopimaric acid

Modify Date: 2024-01-17 18:23:48

Dihydroisopimaric acid Structure
Dihydroisopimaric acid structure
Common Name Dihydroisopimaric acid
CAS Number 5673-36-9 Molecular Weight 304.467
Density 1.0±0.1 g/cm3 Boiling Point 416.8±34.0 °C at 760 mmHg
Molecular Formula C20H32O2 Melting Point N/A
MSDS N/A Flash Point 200.5±20.3 °C

 Use of Dihydroisopimaric acid


Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].

 Names

Name (1S,4aR,4bS,7S)-7-ethyl-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
Synonym More Synonyms

 Dihydroisopimaric acid Biological Activity

Description Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].
Related Catalog
In Vitro Effects of these compounds (10 microM) on the membrane potential of HEKBKalphabeta1 were monitored by use of DiBAC(4)(3), a voltage-sensitive dye. Dihydroisopimaric acid induces substantial membrane hyperpolarization. Dihydroisopimaric acid (1-10 microM) activates BKalphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].
References

[1]. Imaizumi Y, et al. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Mol Pharmacol. 2002;62(4):836-846.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 416.8±34.0 °C at 760 mmHg
Molecular Formula C20H32O2
Molecular Weight 304.467
Flash Point 200.5±20.3 °C
Exact Mass 304.240234
PSA 37.30000
LogP 7.10
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.529

 Synonyms

1-Phenanthrenecarboxylic acid,7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-,(1theta-(1alpha,4abeta,4balpha,7alpha,10aalpha))
Podocarp-7-en-15-oic acid,13alpha-ethyl-13-methyl
Isopimaric acid,dihydro
1-Phenanthrenecarboxylic acid,7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-,(1R,4aR,4bS,7S,10aR)
Isopimaric acid,delta7-dihydro
(5ξ,13α)-Pimar-7-en-19-oic acid
delta7-Dihydroisopimaric acid
1-Phenanthrenecarboxylic acid, 7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-, (1S,4aR,4bS,7S)-
15,16-Dihydroisopimaric acid
Dihydroisopimaric acid