- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 25-Hydroxycholesterol
- Price: ￥638.0/5mg ￥3998.0/100mg ￥1408.0/25mg
- Purity: 99.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 25-Hydroxycholesterol
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: 25-hydroxycholesterol(2140-46-7)
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
2140-46-7
2140-46-7 structure
- Name: 25-Hydroxycholesterol
- Chemical Name: 25-hydroxycholesterol
- CAS Number: 2140-46-7
- Molecular Formula: C27H46O2
- Molecular Weight: 402.653
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-02-16 08:00:00
- Modify Date: 2024-01-02 17:33:25
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25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
| Name | 25-hydroxycholesterol |
|---|---|
| Synonyms |
25-Hydroxy Cholesterol
(3β,9β,14β)-Cholest-5-ene-3,25-diol Cholest-5-ene-3,25-diol, (3β,9β,14β)- (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Description | 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.653 |
| Flash Point | 213.5±17.2 °C |
| Exact Mass | 402.349792 |
| PSA | 40.46000 |
| LogP | 7.66 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.538 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335-H373 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22-36/37/38-48 |
| Safety Phrases | 26-36-45 |
| RIDADR | NONH for all modes of transport |