20501-56-8

20501-56-8 structure

Name: talatisamine
Chemical Name: talatisamine
CAS Number: 20501-56-8
Molecular Formula: C₂₄H₃₉NO₅
Molecular Weight: 421.570
Catalog: Natural product Alkaloid
Create Date: 2018-05-15 08:00:00
Modify Date: 2024-01-11 20:17:50
Talatisamine, a aconitum alkaloid，is specific K+ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons[1].

Name	talatisamine
Synonyms	talatizamine Talatisamine (1α,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol 20-Ethyl-1-α,16-β-dimethoxy-4-(methoxymethyl)aconitane-8,14-α-diol Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,4β,14α,16β)- (16S)-20-ethyl-1α,16-dimethoxy-4-methoxymethyl-aconitane-8,14α-diol (16S)-20-Aethyl-1α,16-dimethoxy-4-methoxymethyl-aconitan-8,14α-diol Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,14α,16β)- (1α,4β,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol

Description	Talatisamine, a aconitum alkaloid，is specific K+ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Wang Y, et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci Lett. 2012 Jun 19;518(2):122-7.