193527-91-2
193527-91-2 structure
- Name: IPAG
- Chemical Name: 1-(4-iodophenyl)-3-(2-adamantyl)guanidine
- CAS Number: 193527-91-2
- Molecular Formula: C17H22IN3
- Molecular Weight: 395.28
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2016-01-14 13:25:18
- Modify Date: 2024-01-09 13:58:52
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IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2].
| Name | 1-(4-iodophenyl)-3-(2-adamantyl)guanidine |
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| Synonyms | ipag |
| Description | IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2]. |
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| Related Catalog | |
| In Vitro | Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[2]. IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass[3]. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[3]. Cell Viability Assay[3] Cell Line: T47D cells Concentration: 10 μM Incubation Time: 24 hours Result: The mean forward scatter height (FSC-H) of DMSO (control) measured 412±5, whereas the mean FSC-H of IPAG treated cells was 390±4. Western Blot Analysis[3] Cell Line: T47D cells Concentration: 10 μM Incubation Time: Result: Decreased levels of phospho-threonine 389-p70S6Kinase (P-S6K), phospho-serine 235/236-ribosomal S6 (P-S6), and phospho-serine 65-4E-BP1 (P-4E-BP1). |
| References |
| Molecular Formula | C17H22IN3 |
|---|---|
| Molecular Weight | 395.28 |
| Exact Mass | 395.08600 |
| PSA | 47.91000 |
| LogP | 4.61580 |