IPAG
Modify Date: 2024-01-09 13:58:52
IPAG structure
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Common Name | IPAG | ||
|---|---|---|---|---|
| CAS Number | 193527-91-2 | Molecular Weight | 395.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H22IN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IPAGIPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2]. |
| Name | 1-(4-iodophenyl)-3-(2-adamantyl)guanidine |
|---|---|
| Synonym | More Synonyms |
| Description | IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[2]. IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass[3]. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[3]. Cell Viability Assay[3] Cell Line: T47D cells Concentration: 10 μM Incubation Time: 24 hours Result: The mean forward scatter height (FSC-H) of DMSO (control) measured 412±5, whereas the mean FSC-H of IPAG treated cells was 390±4. Western Blot Analysis[3] Cell Line: T47D cells Concentration: 10 μM Incubation Time: Result: Decreased levels of phospho-threonine 389-p70S6Kinase (P-S6K), phospho-serine 235/236-ribosomal S6 (P-S6), and phospho-serine 65-4E-BP1 (P-4E-BP1). |
| References |
| Molecular Formula | C17H22IN3 |
|---|---|
| Molecular Weight | 395.28 |
| Exact Mass | 395.08600 |
| PSA | 47.91000 |
| LogP | 4.61580 |
| ipag |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: IPAG
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: IPAG
- Price: $600.0/100mg $1100.0/250mg $2200.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: IPAG
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-(4-IODOPHENYL)-3-(2-ADAMANTYL)GUANIDINE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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