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64706-54-3

64706-54-3 structure
64706-54-3 structure
  • Name: BEPRIDIL HYDROCHLORIDE MONOHYDRATE
  • Chemical Name: bepridil
  • CAS Number: 64706-54-3
  • Molecular Formula: C24H34N2O
  • Molecular Weight: 366.54000
  • Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
  • Create Date: 2018-07-06 09:06:45
  • Modify Date: 2024-01-15 11:40:37
  • Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].
Name bepridil
Synonyms Org 5730
Bepridil (INN)
Bepadin
N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline
Vascor
Bepadin (TN)
Cordium
CERM 1978
Description Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].
Related Catalog
Target

Calcium channel, Sodium channel, SARS-CoV-2[1][2]
References

[1]. Yatani A, et al. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17.

[2]. Vatansever EC, et al. Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2012201118.
Density 1.054 g/cm3
Boiling Point 492.3ºC at 760 mmHg
Molecular Formula C24H34N2O
Molecular Weight 366.54000
Flash Point 133.2ºC
Exact Mass 366.26700
PSA 15.71000
LogP 4.76810
Index of Refraction 1.572

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9710500
CHEMICAL NAME :
1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmeth yl)-
CAS REGISTRY NUMBER :
64706-54-3
LAST UPDATED :
199707
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C24-H34-N2-O
MOLECULAR WEIGHT :
366.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
180 mg/kg/30D-I
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 111,1005,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
90 mg/kg/3W-I
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 111,1005,1986
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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