BEPRIDIL HYDROCHLORIDE MONOHYDRATE

Modify Date: 2024-01-15 11:40:37

BEPRIDIL HYDROCHLORIDE MONOHYDRATE structure	Common Name	BEPRIDIL HYDROCHLORIDE MONOHYDRATE
	CAS Number	64706-54-3	Molecular Weight	366.54000
	Density	1.054 g/cm3	Boiling Point	492.3ºC at 760 mmHg
	Molecular Formula	C₂₄H₃₄N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	133.2ºC

Use of BEPRIDIL HYDROCHLORIDE MONOHYDRATE

Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].

Name	bepridil
Synonym	More Synonyms

Description	Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	Calcium channel, Sodium channel, SARS-CoV-2[1][2]
References	[1]. Yatani A, et al. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17. [2]. Vatansever EC, et al. Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2012201118.

Density	1.054 g/cm3
Boiling Point	492.3ºC at 760 mmHg
Molecular Formula	C₂₄H₃₄N₂O
Molecular Weight	366.54000
Flash Point	133.2ºC
Exact Mass	366.26700
PSA	15.71000
LogP	4.76810
Index of Refraction	1.572

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9710500

CHEMICAL NAME :: 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmeth yl)-

CAS REGISTRY NUMBER :: 64706-54-3

LAST UPDATED :: 199707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H34-N2-O

MOLECULAR WEIGHT :: 366.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 180 mg/kg/30D-I

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 111,1005,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 90 mg/kg/3W-I

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 111,1005,1986

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Org 5730

Bepridil (INN)

Bepadin

N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline

Vascor

Bepadin (TN)

Cordium

CERM 1978

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BEPRIDIL HYDROCHLORIDE MONOHYDRATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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