1405-37-4

1405-37-4 structure

Name: Capreomycin Sulfate
Chemical Name: Capreomycin sulfate
CAS Number: 1405-37-4
Molecular Formula: C₂₅H₄₆N₁₄O₁₁S
Molecular Weight: 750.78
Catalog: API Antibiotics Peptide
Create Date: 2018-03-21 08:00:00
Modify Date: 2024-01-02 10:12:03
Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis.IC50 value:Target: The drug should not be given with streptomycin or other drugs that may damage the auditory vestibular nerve. Patients on this drug will often require audiology tests. It is a cyclic peptide.Capreomycin is administered intramuscularly and shows bacteriostatic activity.

Name	Capreomycin sulfate
Synonyms	N-{[(2S,5S,8Z,11S,15S)-15-Amino-11-[(4R)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-8-[(carbamoylamino)methylene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}-L-ornithinamide sulfate (1:1) EINECS 215-776-8 Capastat sulfate Pentanamide, 2,5-diamino-N-[[(2S,5S,8Z,11S,15S)-15-amino-8-[[(aminocarbonyl)amino]methylene]-11-[(4R)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-5-yl]methyl]-, (2S)-, sulfate (1:1) (salt) MFCD00079032 Capreomycin (sulfate)

Description	Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis.IC50 value:Target: The drug should not be given with streptomycin or other drugs that may damage the auditory vestibular nerve. Patients on this drug will often require audiology tests. It is a cyclic peptide.Capreomycin is administered intramuscularly and shows bacteriostatic activity.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Johansen SK, et al. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Mol Cell. 2006 Jul 21;23(2):173-82.

Boiling Point	1376.7ºC at 760mmHg
Molecular Formula	C₂₅H₄₆N₁₄O₁₁S
Molecular Weight	750.78
Flash Point	786.4ºC
PSA	458.90000
Vapour Pressure	0mmHg at 25°C
Storage condition	−20°C
Water Solubility	H2O: soluble50mg/mL \| Freely soluble in water

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,175,1982

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5273 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 307 (estimated) No. of Female Employees: 251 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302 + H312 + H332-H360
Precautionary Statements	P201-P261-P280-P301 + P312 + P330-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R61
Safety Phrases	53-22-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	EX8930000