Capreomycin Sulfate

Modify Date: 2024-01-02 10:12:03

Capreomycin Sulfate structure	Common Name	Capreomycin Sulfate
	CAS Number	1405-37-4	Molecular Weight	750.78
	Density	N/A	Boiling Point	1376.7ºC at 760mmHg
	Molecular Formula	C₂₅H₄₆N₁₄O₁₁S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	786.4ºC
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Capreomycin Sulfate

Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis.IC50 value:Target: The drug should not be given with streptomycin or other drugs that may damage the auditory vestibular nerve. Patients on this drug will often require audiology tests. It is a cyclic peptide.Capreomycin is administered intramuscularly and shows bacteriostatic activity.

Name	Capreomycin sulfate
Synonym	More Synonyms

Description	Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis.IC50 value:Target: The drug should not be given with streptomycin or other drugs that may damage the auditory vestibular nerve. Patients on this drug will often require audiology tests. It is a cyclic peptide.Capreomycin is administered intramuscularly and shows bacteriostatic activity.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Johansen SK, et al. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Mol Cell. 2006 Jul 21;23(2):173-82.

Boiling Point	1376.7ºC at 760mmHg
Molecular Formula	C₂₅H₄₆N₁₄O₁₁S
Molecular Weight	750.78
Flash Point	786.4ºC
PSA	458.90000
Vapour Pressure	0mmHg at 25°C
Storage condition	−20°C
Water Solubility	H2O: soluble50mg/mL \| Freely soluble in water

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX8930000

CHEMICAL NAME :: Capreomycin, sulfate (salt)

CAS REGISTRY NUMBER :: 1405-37-4

LAST UPDATED :: 199504

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1191 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 514 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,175,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5273 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 307 (estimated) No. of Female Employees: 251 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302 + H312 + H332-H360
Precautionary Statements	P201-P261-P280-P301 + P312 + P330-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R61
Safety Phrases	53-22-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	EX8930000

Antibiotic Susceptibility Patterns of Mycobacterium tuberculosis Isolates from Guizhou Province of China Against 13 Antituberculosis Drugs.

Microb. Drug Resist. 21 , 292-6, (2015)

A total of 92 Mycobacterium tuberculosis isolates were collected from patients with pulmonary tuberculosis (TB) in the Zunyi region between 2011 and 2012. Collected isolates were used to determine ant...

Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

Antimicrob. Agents Chemother. 55 , 4712 - 4717, (2011)

Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both ...

Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis.

Antimicrob. Agents Chemother. 49 , 571-577, (2005)

Capreomycin, an important drug for the treatment of multidrug-resistant tuberculosis, is a macrocyclic peptide antibiotic produced by Saccharothrix mutabolis subspecies capreolus. The basis of resista...

N-{[(2S,5S,8Z,11S,15S)-15-Amino-11-[(4R)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-8-[(carbamoylamino)methylene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}-L-ornithinamide sulfate (1:1)

EINECS 215-776-8

Capastat sulfate

Pentanamide, 2,5-diamino-N-[[(2S,5S,8Z,11S,15S)-15-amino-8-[[(aminocarbonyl)amino]methylene]-11-[(4R)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-5-yl]methyl]-, (2S)-, sulfate (1:1) (salt)

MFCD00079032

Capreomycin (sulfate)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Capreomycin Sulfate
Price: ￥2258.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Capreomycin sulfate
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Capastat sulfate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Capastat sulfate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: $198/10mM*1mLinWater

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Capreomycin Sulfate

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