49863-47-0

49863-47-0 structure

Name: g418
Chemical Name: geneticin
CAS Number: 49863-47-0
Molecular Formula: C₂₀H₄₀N₄O₁₀
Molecular Weight: 496.55200
Catalog: Inorganic chemical industry Inorganic salt Metal sulfides and sulfates
Create Date: 2018-03-10 08:00:00
Modify Date: 2024-01-08 17:40:09
G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

Name	geneticin
Synonyms	Gentamicin G-418 Gentamycin B (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Betamicina [INN-Spanish] Gentamicin B Betamicina BETAMICIN Betamicinum [INN-Latin] Betamicine [INN-French] Betamicin [INN]

Description	G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	G-418 (500 μg/mL，12 days) 用于筛选耐药性 LNCaP 细胞[1]。
References	[1]. S Bennett, et al. Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. Biotechniques. 1997 Jul;23(1):66, 68, 70.

CHEMICAL NAME :: D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopy ranosyl-(1-4)-O- (3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyr anosyl-(1-6))-

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ FYQ1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DM1 EQ E1

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,67,1993