g418

Modify Date: 2024-01-08 17:40:09

g418 Structure
g418 structure
Common Name g418
CAS Number 49863-47-0 Molecular Weight 496.55200
Density 1.47 g/cm3 Boiling Point 760.3ºC at 760 mmHg
Molecular Formula C20H40N4O10 Melting Point N/A
MSDS N/A Flash Point 413.6ºC

 Use of g418


G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

 Names

Name geneticin
Synonym More Synonyms

 g418 Biological Activity

Description G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].
Related Catalog
In Vitro G-418 (500 μg/mL,12 days) 用于筛选耐药性 LNCaP 细胞[1]。
References

[1]. S Bennett, et al. Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. Biotechniques. 1997 Jul;23(1):66, 68, 70.  

 Chemical & Physical Properties

Density 1.47 g/cm3
Boiling Point 760.3ºC at 760 mmHg
Molecular Formula C20H40N4O10
Molecular Weight 496.55200
Flash Point 413.6ºC
Exact Mass 496.27400
PSA 248.39000
Storage condition 2-8°C
Water Solubility H2O: 50 mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WK2132600
CHEMICAL NAME :
D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopy ranosyl-(1-4)-O- (3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyr anosyl-(1-6))-
CAS REGISTRY NUMBER :
49863-47-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H40-N4-O10
MOLECULAR WEIGHT :
496.64
WISWESSER LINE NOTATION :
T6OTJ CZ DQ EQ FYQ1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DM1 EQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Fibroblast
DOSE/DURATION :
75 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,67,1993

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 22-24/25
WGK Germany 3

 Synonyms

Gentamicin G-418
Gentamycin B
(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
Betamicina [INN-Spanish]
Gentamicin B
Betamicina
BETAMICIN
Betamicinum [INN-Latin]
Betamicine [INN-French]
Betamicin [INN]