Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Octanol
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Purity: 98.0%
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111-87-5

111-87-5 structure

Name: 1-Octanol
Chemical Name: octan-1-ol
CAS Number: 111-87-5
Molecular Formula: C₈H₁₈O
Molecular Weight: 130.22800
Catalog: Organic raw materials Alcohols, phenols, phenolic compounds and derivatives Acyclic alcohol
Create Date: 2018-09-16 18:18:26
Modify Date: 2026-06-30 11:49:09
1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2].

Name	octan-1-ol
Synonyms	1-OCTANOL NATURAL FCC [14C]-n-Octanol n-Htyl cbinol Dytol m-83 femanumber2800 1-OCTANOL, ANHYDROUS 1-OCTANOL A.C.S. SPECTROPHOTOMET& 1-OCTANOL EMPLURA 1 L EINECS 203-917-6 1-octyl alcohol OCTAN-1-OL n-Octano OCTYL ALCOHOL Lorol 20 Octilin 1-OCTANOL HPLC ADE 1-OCTANOL, FOR UV SPECTROSCOPY N-CAPRYLIC ALCOHOL Alfol 8 caprylic MFCD00002988 alfol8 1-Octanol anhydrous, AcroSeal Lorol C8 1-OCTANOL A.C.S. SPECTROPHOTOMETR IC ADE Capryl alcohol HTYL CBINOL OCTANOL-1 FCC al 8 lorol20 N-CAPRYL ALCOHOL sipoll8 ctanol OCTANOL,1 1-OCTANOL, REAGENTPLUS N-OCTANOL 1-OCTANOL A.C.S 1-OCTANOL, 1000MG, NEAT CAPRYL ALCOHOL 1-Octanol SpcDry, WaterppM (by K.F.), SpcSeal alcooln-octylique n-octyl alcohol OCTANOL CAPRYLIC ALCOHOL 1-Octanol, SuperDry, J&KSeal 1-Hydroxyoctane Epal 8 1-OCTANOL FCC Emery caprylicalcohol(octylalcohol) octan-1 1-OCTANOL N-OCTYL ALCOHOL, PRIMY N-OCTYL ALCOHOL al8 n-Octan-1-ol ALCOHOL C-8 caprylic alcohol octanol,1-octanol 1-OCTANOL EMPLURA 25 L dytolm-83

Description	1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	T-type calcium channel:4 μM (IC50) Human Endogenous Metabolite
In Vitro	1-octanol inhibits native T-currents at subanesthetic concentrations with an IC50 of approximately 4 μM. In contrast, 1-octanol is up to 30-fold less potent in inhibiting recombinant CaV3.3 T-channels heterologously expressed in human embryonic kidney cells[1].
References	[1]. Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94. [2]. Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 13;2:1-5.

Density	0.827 g/mL at 25 °C(lit.)
Boiling Point	196 °C(lit.)
Melting Point	−15 °C(lit.)
Molecular Formula	C₈H₁₈O
Molecular Weight	130.22800
Flash Point	178 °F
Exact Mass	130.13600
PSA	20.23000
LogP	2.33920
Vapour density	4.5 (vs air)
Vapour Pressure	0.14 mm Hg ( 25 °C)
Index of Refraction	n20/D 1.429(lit.)
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.
Water Solubility	insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RH6550000

CHEMICAL NAME :: Octyl alcohol

CAS REGISTRY NUMBER :: 111-87-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C8-H18-O

MOLECULAR WEIGHT :: 130.26

WISWESSER LINE NOTATION :: Q8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 mg/m3/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 69 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 800 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80235 No. of Facilities: 1071 (estimated) No. of Industries: 29 No. of Occupations: 32 No. of Employees: 13905 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80235 No. of Facilities: 9310 (estimated) No. of Industries: 133 No. of Occupations: 93 No. of Employees: 287737 (estimated) No. of Female Employees: 72792 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H412
Precautionary Statements	P273-P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/38
Safety Phrases	S26-S36/37-S37/39
RIDADR	3082
WGK Germany	1
RTECS	RH6550000
Packaging Group	III
Hazard Class	9
HS Code	2905161000

Precursor 10
111-11-5 1369416-85-2 2548-87-0 1118-92-9
629-05-0 6998-10-3 3208-43-3 124-07-2
124-13-0 92976-53-9
DownStream 10
106144-21-2 104483-29-6 100386-17-2 94-50-8
10348-34-2 104483-19-4 109-36-4 32953-65-4
67-56-1 1071-67-6