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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Kojic acid
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501-30-4

501-30-4 structure

501-30-4 structure

Name: kojic acid
Chemical Name: kojic acid
CAS Number: 501-30-4
Molecular Formula: C₆H₆O₄
Molecular Weight: 142.11
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyran compound
Create Date: 2018-02-06 08:00:00
Modify Date: 2026-06-30 18:51:24
Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent[1].

Name	kojic acid
Synonyms	Kojic Acid (5-Hydroxy-2-hydroxymethyl-4-pyrone) 2-(hydroxymethyl)-5-hydroxy-4H-pyran-4-one 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone 2-Hydroxymethyl-5-hydroxy-γ-pyrone 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE skin whitening effect kojic acid 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 2-HYDROXYMETHYL-5-HYDROXY-4-PYRONE KojicAcid> 4H-PYRAN-4-ONE,5-HYDROXY-2-(HYDROXYMETHYL) 5-hydroxy-2-(hydroxmetyl)-4H-pyran-4-one KOJIC ACID CRYSTALLINE 5-hydroxy-2-(hydroxymethyl)pyran-4-one 5-Hydroxy-2-(hydroxymethyl) 5-Hydroxy-2-(hydroxyMethyl)-4H-pyranone 5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRONE Kojic acid, R 5-HYDROXY-2-HYDROXYMETHYL-4H-4-PYRANONE KOJICACID(BULK aKojic acid EINECS 207-922-4 UNII-6K23F1TT52 5-Hydroxy-2-(hydroxymethyl)-4-pyrone LABOTEST-BB LT00068503 Kojic Impurity 1 5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-on Iridium(III) chloride hydrate 14-3 acid powder 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one Solution Kojci Acid kojic 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) Pyran-4-one, 5-hydroxy-2-(hydroxymethyl) Kojic acid extrapure kojic acid powder TIMTEC-BB SBB005397 KOJIC ACID SOLUTION [FOR SPRAY] 2-HYDROXYMETHYL-5-HYDROXY-1,4-PYRONE 5-Hydroxy-2-(hydroxymethyl)-γ-pyrone KJ ACID Skin Whitening Kojic Acid Powder 3-hydroxy-6-hydroxymethyl-4H-pyran-4-one Kojic acid(whitening agent in cosmetic) 2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone Kojic acid2-Hydroxymethyl-5-hydroxy-γ-pyrone 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone MFCD00006580 KOJIC ACID(RG) 2-HYDROXYMETHYL-5-HYDROXY-GAMMA-PYRONE 5'-HYDROXY-2-(HYDROXYMETHYL)-1,4-PYRANONE High Quality Skin whitening organic acide kojic Kojic acid ISO 9001：2015 REACH Nano Liposomal Kojicacid Kojic acid 4-Oxo-5-hydroxy-4H-pyran-2-methanol 5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one Kojicacid KNUDSON C ORCHID MEDIUM 4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl) 5-HYDROXY-2-HYDROXYMETHYL-PYRAN-4-ONE 2-hydroxymethyl-5-hydroxy-γ-pyrone Kojic Acid Solution 5-HYDROXY-2-HYDROXYMETHYL-4-PYRANONE

Description	Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183.

Density	1.5±0.1 g/cm3
Boiling Point	401.7±45.0 °C at 760 mmHg
Melting Point	152-155 °C(lit.)
Molecular Formula	C₆H₆O₄
Molecular Weight	142.11
Flash Point	179.9±22.2 °C
Exact Mass	142.026611
PSA	70.67000
LogP	-0.64
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.607
Storage condition	Refrigerator
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	SOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0875000

CHEMICAL NAME :: 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 501-30-4

BEILSTEIN REFERENCE NO. :: 0120895

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H6-O4

MOLECULAR WEIGHT :: 142.12

WISWESSER LINE NOTATION :: T6O DVJ B1Q EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 4500 mg/L

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 59,213,1991

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R40
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ0875000
HS Code	29329995

Precursor 10
7559-81-1 67-64-1 58-86-6 5328-37-0
26209-93-8 50-99-7 56-81-5 50-70-4
608-66-2 87-89-8
DownStream 10
496-63-9 31883-16-6 1429-25-0 443955-90-6
443955-89-3 216581-47-4 2029-49-4 644-46-2
6323-21-3 6269-25-6

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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